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KMID : 0363819960300030351
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Korean Journal of Nuclear Medicine
1996 Volume.30 No. 3 p.351 ~ p.360
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Study on the Preparations of New ^(166)Ho-Chitosan Complex and Iv
Macroaggregates for a Potential Use of Internal Radiotherapy
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박경배/Park, K.B.
김영미/신병철/김재록/Kim, Y.M./Shin, B.C./Kim, J.R.
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Abstract
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Chitosan is a polysaccharide of natural orgin obtained by full or partial deace:=mar of chitin, a very abudant natural polymer, which has the properties of biocompati´ - - bioaffinities, and biodegradabilities. The free amino group of chitosan shop- x participated in forming chelate with holmium (,8 -emitter). 166Ho(N03)3 . 5H20 o radionuclidic purity of upto 99.9% was made by neutron irradiation of naturally ocz
1651Io(N03)3 ? 5H20, and then reacted with the prepared chitosan solution. The e~~- - pH, reaction time, the concentration and viscosity of chitosan and the amount of on forming 166Ho-chitosan complex (16Ho-CHICO) were investigated. 166Ho-r-P-macroaggregate(166Ho-CHIMA) was made from 166Ho-CHICO. Their physical prcc s such as radionuclidic purity, particle size distribution, stability in vitro and vivo examined. Their high in vitro and vivo stability makes them attractive ages internal radiotherapy by local administeration.
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KEYWORD
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